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HypnoVR, the leader in virtual reality medical hypnosis, and Mdoloris Medical Systems, the leader in continuous, non-invasive monitoring of the parasympathetic tone, have joined forces to develop the next generation of therapeutic virtual reality dedicated to the treatment of pain and anxiety. The HypnoVR solution integrates Mdoloris Medical Systems ANI technology (Analgesia Nociception Index), which enables real-time measurement of the nervous system activity of hospitalized patients. A partnership that combines, for the first time, digital therapy with real-time monitoring of the patient’s condition to offer a personalized treatment to fight pain and anxiety. 

Launched on the digital therapy market in 2016 and now used daily by more than 280 hospitals, HypnoVR’s digital therapy has been proven to reduce patients’ anxiety and pain before, during and after medical procedures, also participating in the reduction of sedative use and thus reducing the risks of complications. Validated by more than 17 clinical studies (, HypnoVR’s digital therapy is based on a purely scientific approach coupled with a dynamic of innovation thanks to the involvement of experts from the medical and digital world. 

HypnoVR is partnering with Mdoloris Medical Systems to take its hypnotherapy solution a step further and significantly improves the control of care in a non-invasive and non-drug way. This partnership is above all the association of two experts in pain and anxiety: HypnoVR for their treatment and Mdoloris for their measurement.

As a result of their joint work, HypnoVR is launching the first HypnoVR Biofeedback prototype incorporating the latest MDoloris technology, the ANI GUARDIAN, which captures, analyzes, and reports nervous system responses to pain and anxiety in real time. Reliable, continuous, and non-invasive, it remotely shares data to caregivers, family, and medical specialists in real time. Ideal for both indoor and outdoor use, the wireless bracelet features a 24 continuous monitoring for a 1-hour charge, needs no installation and eases the lives of patients under care. 

We are excited to announce this OEM integration in this niche segment where few companies have a proven positive track record. This partnership with HypnoVR proves once again the effectiveness and accuracy of the technology developed by Mdoloris, which will allow to adapt and customize the hypnosis process provided by HypnoVR. A partnership that will put the patient first“, says Fabien Pagniez, CEO of Mdoloris Medical Systems.

This prototype is the result of 3 years of research (1 thesis, 2 scientific papers) conducted by HypnoVR in collaboration with three CNRS laboratories: the Laboratory of Engineering, Computer Science and Imaging (ICUBE), the Center for Neurocognitive and Neurophysiological Investigation (CI2N) and the Institute of Cellular and Integrative Neuroscience (INCI) (winning research project of the national innovation competition iNOV). 

The ANI of Mdoloris is the physiological biomarker chosen for its performance, its recognition and its validation by numerous studies. The HypnoVR Biofeedback product is therefore the result of a partnership between 2 startups from the French ecosystem.

True to its commitment to innovation, HypnoVR is proud to launch the first version of this new prototype – HypnoVR Biofeedback – delivering a therapeutic virtual reality that adapts to the patient’s condition in real time. It will allow better pain and anxiety management during medical procedures depending on the patient. “As discovery-driven and science-based companies, our partnership represents a unique opportunity to develop the next generation of digital therapies and continue to create the medical world of tomorrow” says Nicolas Schaettel, CEO of HypnoVR.

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